Copper Transporting ATPase 1 Antibody: RPE

Biorbyt

Copper Transporting ATPase 1 antibody

10

1 microg/ml of SMC-398 was sufficient for detection of Copper-transporting ATPase1 in 20 microg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

WB (1:500), ICC/IF (1:100) ICC, IF, IHC, WB

Research Use Only

Monoclonal

L60/4 (Formerly sold as S60-4)

1 mg/ml

RPE

ATP7A

ATPase copper transporting alpha

ATPase, Cu++ transporting, alpha polypeptide; copper pump 1; copper-transporting ATPase 1; Cu++-transporting P-type ATPase; DSMAX; Menkes disease-associated protein; MK; MNK; SMAX3

Mouse

IgG2b

Copper-transporting ATPase 1

Mouse monoclonal to Copper Transporting ATPase 1 (RPE). The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-trans locating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood. Mutations in the ATP7B gene lead to the autosomal recessive disorder, Wilson disease, characterized by neurological symptoms and hepatic damage..

Human, Mouse, Rat

See Manual

12352203