COPS8 Antibody, Biotin conjugated

Cusabio

COPS8 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

COPS8

COP9 signalosome subunit 8

COP9; COP9 constitutive photomorphogenic homolog subunit 8; COP9 homolog; COP9 signalosome complex subunit 8; CSN8; hCOP9; JAB1-containing signalosome subunit 8; SGN8; signalosome subunit 8

Rabbit

IgG

COP9 signalosome complex subunit 8

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Human

-20°C or -80°C

12352203