Anti-ACE2, clone 4G5.1 | MABN59 | Merck - Bio-Connect

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Description
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General

Product specifications for - Anti-ACE2, clone 4G5.1

Overview:
Product group:	Corona Related Products
Category:	Primary Antibodies
Application:	ELISA
Application note:	ELISA Analysis: A representative lot detected ACE2 in a direct ELISA.
Host:	Mouse
Target:	ACE2
Target description:	angiotensin I converting enzyme 2
Clonality:	Monoclonal

Properties:
	Research Use Only
UNSPSC:	12352203
Storage instructions:	Stable for 1 year at 2-8-¦C from date of receipt.

Scientific information:
Scientific info:	ACE2 (Angiotensin-converting enzyme 2) is a transmembrane protein belonging to the peptidase M2 family. It is expressed in vascular endothelial cells of the heart, kidney, testis, and gastrointestinal system. ACE2 produces Angiotensin (1-9) by hydrolysis of Angiotensin 1. Angiotensin (1-9) is a precursor for Angiotensin (1-7). ACE2 may also directly produce Angiotensin (1-7) by conversion of Angiotensin II, which is involved in vasoconstriction. Angiotensin (1-7) plays an important role in the RAS signaling pathway and is involved in vasodilation. Hence, ACE2 antagonizes the effects of its homolog, ACE. ACE2 is insensitive to commonly used inhibitors such as linosipril and captopril. ACE2 is upregulated in heart failure, possibly in response to overactivity of Angiotensin II, ACE2 is studied for its potential therapeutic value for hypertension and heart failure.
Clone ID:	4G5.1
Gene ID:	59272

Additional information:
Synonyms:	MABN59; Merck (Millipore)