Chloroquine (phosphate) [50-63-5]

Catalog number: HY-17589_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: 10 mM
Price: € 95.00
Expected delivery time: 10 days

Product specifications for - Chloroquine (phosphate) [50-63-5]

Product group: Corona Related Products
Category: Other
CAS No.: 50-63-5
Purity: >98%
Molecular Formula: C18H32ClN3O8P2
Molecular weight: 515.86
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Chloroquine diphosphate is an antimalarial drug and autophagy/lysosome inhibitor, inhibits Toll-like receptor (TLR) signalling in plasmacytoid dendritic cells (pDCs). IC50 value: Target: in vitro: CHQ-treated MoLC promoted IL-17A secretion by CD4(+) T cells and elevated RORC mRNA levels, whereas IFN-gamma release was reduced. The dysregulation of IL-12 family cytokines in MoLC and MoDC occurred at the transcriptional level [1]. CQ was well tolerated and all patients maintained an undetectable VL. The absolute CD4 and CD8 T-cell counts and their percentages, the pDC proportion, T-cell activation, D-dimer and C-reactive protein (CRP) plasma levels and the kynurenine/tryptophan ratio did not change with CQ treatment. Among nine cytokines/chemokines measured, only levels of interferon (IFN)-alpha2 were significantly increased by CQ treatment [2]. Chloroquine suppressed matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expression and protein activity, whereas MMP-13 mRNA expression and proteolytic activity were increased. Despite enhancing TLR9 mRNA expression, chloroquine suppressed TLR9 protein expression in vitro [3]. in vivo: Daily treatment of mice with intraperitoneal (i.p.) chloroquine (80 mg/kg/day) for 22 days, did not inhibit the growth of control siRNA or TLR9 siRNA MDA-MB-231 breast cancer cells [3]. Proliferation of HuH7 cells in vitro increased significantly in response to stimulation of TLR7. TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly reduced HuH7 cell proliferation in vitro and inhibited tumour growth in the mouse xenograft model [4].
Safety information: 
WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation', Y Feng. Acta Biochim Biophys Sin (Shanghai). 2016 Dec;48(12):1075-1084. Read more
Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy', Yang Z. EBioMedicine. 2017 May;19:49-59. Read more
SUSD2 promotes cancer metastasis and confers cisplatin resistance in high grade serous ovarian cancer', Xu Y. Exp Cell Res. 2018 Jan 2. pii: S0014-4827(17)30691-2. Read more