Coronavirus SARS-CoV-2 NSP14 (exonuclease) protein (Recombinant 6His, N-terminus) (Ala1-Gln527)

LifeSpan BioSciences

Coronavirus SARS-CoV-2 NSP14 (exonuclease) protein (Recombinant 6His, N-terminus) (Ala1-Gln527)

23

Research Use Only

0.48 mg/ml

>85%

The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3 to 5 direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). SARS-CoV 2 polyproteins incorporate 16 protein domains (nsps). The putative non-structural protein 2 (nsp2) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development.

-20°C

12352202