Coronavirus SARS-CoV-2 Nucleoprotein (Recombinant 6His, C-terminus) (Met1-Ala419)

LifeSpan BioSciences

Coronavirus SARS-CoV-2 Nucleoprotein (Recombinant 6His, C-terminus) (Met1-Ala419)

23

Research Use Only

>90%

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.

2°C to 8°C,-20°C,-20°C or -80°C

12352202