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CgoaEGY7LtCEXDx5AAAAAK5C-OY767.png
CgoaEGY7LtCEXDx5AAAAAK5C-OY767.png

Cot inhibitor-1

Research Use Only
T10865
TargetMol Chemicals
CAS Number915365-57-0
Product group Chemicals
Molecular Weight553.46
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Cot inhibitor-1
  • Delivery Days Customer
    4
  • CAS Number
    915365-57-0
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Cot inhibitor-1
  • Molecular Formula
    C27H27Cl2FN8
  • Molecular Weight
    553.46
  • Scientific Description
    Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation and immune responses. Cot inactivate-1 inhibits Cot activity and may have potential therapeutic effects on rheumatoid arthritis, inflammatory bowel disease and some types of cancer.
  • Shelf life instruction
    3 years
  • SMILES
    N(C=1C2=C(C(Cl)=CC(NCC3=CN(CCN4CCCCCC4)N=N3)=C2)N=CC1C#N)C5=CC(Cl)=C(F)C=C5
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Wu J, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009;19(13):3485-3488.
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