Cotransin [863753-73-5]

TargetMol Chemicals

Cotransin [863753-73-5]

16

Research Use Only

C42H68N6O8

785.02

Cotransin, a Sec61 translocation inhibitor, selectively prevents the stable insertion of certain nascent chains into the Sec61 translocation channel, exhibiting signal-sequence discrimination. This compound also inhibits the expression of VCAM-1 and p-selectin proteins by blocking their co-translational translocation across endoplasmic reticulum (ER) membranes (IC 50 =0.5-5 microM). Cotransins role extends to potential applications in inflammation and immunity research [1] [2].

C([C@@H]1N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)OC(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC1=O)C2=CC=CC=C2

-20°C

12352200