Covidcil-19

MedChem Express

Covidcil-19 [1225177-95-6]

14

1225177-95-6

Research Use Only

C16H14N4O2

294.31

Covidcil-19 (compound C5) avidly binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with a Kd of 11 nM. Covidcil-19 stabilizes the hairpins folded state and impairs frameshifting in cells. Covidcil-19 reduces frameshifting efficiency of the SARS-CoV-2 FSE and does not affect SARS-CoV-2 FSE RNA levels. Covidcil-19 inhibits a process essential for SARS-CoV-2 viral propagation[1].

O=C(C1=CC(NC2=NC(NC)=C3C=CC=CC3=N2)=CC=C1)O

12352200