COX-2-IN-48

MedChem Express

COX-2-IN-48

9

Research Use Only

C25H17ClF3NO2

455.86

COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC50 of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-kappaB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IkappaB, the phosphorylation and nuclear translocation of NF-kappaB p65, and the expression of COX-2 and iNOS[1].

FC(C1=C(C2=CC=C(Cl)C=C2)C(C3=CNC4=C3C=CC=C4)C5=C(O1)C=CC(OC)=C5)(F)F

12352200