COX-2/5-LOX-IN-2

MedChem Express

COX-2/5-LOX-IN-2

10

Research Use Only

C18H13N3O4S2

399.44

COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 5.40, 0.01 and 1.78 microM, respectively[1].

OC(C1=NN(C(C2=CC3=C(S2)C=CC=C3)=C1)C4=CC=C(C=C4)S(N)(=O)=O)=O

12352200