CP-868596 (Crenolanib)

Biorbyt

CP-868596 (Crenolanib) [670220-88-9]

16

670220-88-9

C26H29N5O2

443.54

Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRalpha/beta with Kd of 2.1 nM/3.2 nM, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, > 100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB

NC1CCN(C2=CC=CC3=C2N=C(N4C5=CC=C(C=C5N=C4)OCC6(COC6)C)C=C3)CC1

12352200