CRCD2

MedChem Express

CRCD2

9

Research Use Only

99.02

C17H16N4O2S

340.40

CRCD2 is a small molecule NT5C2 nucleotidase inhibitor with enhanced 6-mercaptopurine cytotoxic activity. CRCD2 can effectively reverse 6-mercaptopurine resistance caused by mutations in the NT5C2 gene or non-genetic activation mechanisms. CRCD2 combined with 6-mercaptopurine can enhance its cytotoxic activity in NT5C2 wild-type leukemia, showing its potential in the treatment of acute lymphoblastic leukemia[1].

O=C(C1=C(NC(C2=CC3=C(N=CN3)C=C2)=O)SC4=C1CCCC4)N

-20°C,2°C to 8°C

12352200