CREBZF Polyclonal Antibody

Reddot Biotech

CREBZF Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.4 mg/ml

Unconjugated

CREBZF

CREB/ATF bZIP transcription factor

CREB/ATF bZIP transcription factor; HCF-binding transcription factor Zhangfei; host cell factor-binding transcription factor Zhangfei; SHP-interacting leucine zipper protein; SMILE; ZF; Zhangfei

Rabbit

IgG

Host cell factor (HCF) is a cellular cofactor required for the activation of VP16 which expresses the herpes simplex virus immediate early gene. V16 binds to HCF through a 4-amino acid motif similar to the HCF binding domain of the basic leucine-zipper proteins Luman and Zhangfei (ZF). Luman activates promoters containing cAMP or unfolded protein response elements (UPRE). Zhangfei suppresses the transcriptional activity of Luman, but requires HCF binding which may target Luman and Zhangfei to a common location. Sequence analysis predicts that the deduced 272-amino acid Zhangfei protein has a negatively charged N terminus, a leucine zipper of 6 heptad leucine repeats separated by a conserved 6-amino acid spacer, a basic domain, and a bZIP region. It is also presumed that the N-terminal acidic region of Zhangfei is an activation domain.

Human, Mouse

-20°C

12352203