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cRIPGBM (chloride)

Research Use Only
HY-115630
MedChem Express
Estimated Purity99.73
DownloadMSDS
Product group Chemicals
Molecular Weight446.90
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Overview

  • Supplier
    MedChem Express
  • Product Name
    cRIPGBM (chloride)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    99.73
  • Molecular Formula
    C26H20ClFN2O2
  • Molecular Weight
    446.90
  • Scientific Description
    cRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs). cRIPGBM(chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce caspase 1-dependent apoptosis. cRIPGBM(chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of RIPK2/caspase 1 (proapoptotic complex). cRIPGBM(chloride) exerts potent anti-tumor activity in vivo in animal models[1].
  • SMILES
    O=C(C1=C2[N+](CC3=CC=C(F)C=C3)=C(C)N1CC4=CC=CC=C4)C5=C(C=CC=C5)C2=O.[Cl-]
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200