Western Blot analysis of Mouse heart and Human chromaffin cell tumor tissue, Mouse muscle tissue using Crystallin-alpha B Polyclonal Antibody at dilution of 1:500
Western Blot analysis of Mouse heart and Human chromaffin cell tumor tissue, Mouse muscle tissue using Crystallin-alpha B Polyclonal Antibody at dilution of 1:500
CRYAB Polyclonal Antibody
E-AB-10781
Product group Antibodies
Overview
- SupplierElabscience
- Product NameCRYAB Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA WB IHC
- CertificationResearch Use Only
- Concentration0.2mg/ml
- Scientific DescriptionCrystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone.
- UNSPSC12352203