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CSRM617 [787504-88-5]

CSRM617 [787504-88-5]

Research Use Only
T10896
TargetMol Chemicals
CAS Number787504-88-5
DownloadMSDS
Product group Chemicals
Molecular Weight255.23
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    CSRM617 [787504-88-5]
  • Delivery Days Customer
    72
  • CAS Number
    787504-88-5
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    CSRM617
  • Molecular Formula
    C10H13N3O5
  • Molecular Weight
    255.23
  • Scientific Description
    CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.
  • Shelf life instruction
    3 years
  • SMILES
    C(=NNC(C(CO)N)=O)C1=C(O)C(O)=C(O)C=C1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Rotinen M et al., 2018 Dec, Nat Med
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