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CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10), CF640R conjugate, 0.1mg/mL [26628-22-8]

CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10), CF640R conjugate, 0.1mg/mL [26628-22-8]

BNC401696
Biotium
ReactivityBovine, Human, Mouse, Rat
Product group Antibodies
TargetCTLA4
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Overview

  • Supplier
    Biotium
  • Product Name
    CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10), CF640R conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    L4P2F5.F10
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID1493
  • Target name
    CTLA4
  • Target description
    cytotoxic T-lymphocyte associated protein 4
  • Target synonyms
    ALPS5; CD; CD152; celiac disease 3; CELIAC3; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; GRD4; GSE; IDDM12; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP16410
  • Protein Name
    Cytotoxic T-lymphocyte protein 4
  • Scientific Description
    CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203