![CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10), CF640R conjugate, 0.1mg/mL [26628-22-8] CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10), CF640R conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2021/02/view_image-113.jpeg)
CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10), CF640R conjugate, 0.1mg/mL [26628-22-8]
BNC401696
ReactivityBovine, Human, Mouse, Rat
Product group Antibodies
TargetCTLA4
Overview
- SupplierBiotium
- Product NameCTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10), CF640R conjugate, 0.1mg/mL
- Delivery Days Customer9
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDL4P2F5.F10
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID1493
- Target nameCTLA4
- Target descriptioncytotoxic T-lymphocyte associated protein 4
- Target synonymsALPS5; CD; CD152; celiac disease 3; CELIAC3; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; GRD4; GSE; IDDM12; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
- HostMouse
- IsotypeIgG1
- Protein IDP16410
- Protein NameCytotoxic T-lymphocyte protein 4
- Scientific DescriptionCTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203