CU-76 [2400954-58-5]

TargetMol Chemicals

CU-76 [2400954-58-5]

10

Chemical

Research Use Only

CU-76

C11H8F2IN5O2

407.11

CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 microM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-beta in THP-1 cells when used at concentrations of 10, 30, and 100 microM.

3 years

N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC(F)=C(I)C(F)=C2

-20°C

12352200