CU-CPT-9b

Biorbyt

CU-CPT-9b [2165340-32-7]

16

2165340-32-7

Research Use Only

C17H15NO2

265.31

CU-CPT9a is an antagonist of toll-like receptor 8 (TLR8). It inhibits activation of NF-kappaB induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells (IC50 = 0.5 nM). CU-CPT9a reverses R-848-induced increases in NF-kappaB p65, IRAK-4, and TRAF3 protein levels in HEK-Blue cells.

C(C1=CC=NC2C=C(OC)C=CC1=2)1=CC=C(O)C(C)=C1

12352200