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CUL2 antibody

Research Use Only
ORB67162
Biorbyt
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetCUL2
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Overview

  • Supplier
    Biorbyt
  • Product Name
    CUL2 antibody
  • Delivery Days Customer
    16
  • Applications
    Western Blot
  • Applications Supplier
    WB:1:1000-1:5000 WB
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID8453
  • Target name
    CUL2
  • Target description
    cullin 2
  • Target synonyms
    CUL-2; cullin-2; testis secretory sperm-binding protein Li 238E
  • Host
    Rabbit
  • Protein IDQ13617
  • Protein Name
    Cullin-2
  • Scientific Description
    Rabbit polyclonal to CUL2.Cullin-2 (CUL2) is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCSboxprotein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins.CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioningof the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of thecomplex is dependent on the neddylation of the cullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. ECS(VHL) mediates the ubiquitination of hypoxiainduciblefactor (HIF).
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203