BUB1B Antibody, FITC conjugated
CSB-PA002883LC01HU
ReactivityHuman
Product group Antibodies
TargetBUB1B
Overview
- SupplierCusabio
- Product NameBUB1B Antibody, FITC conjugated
- Delivery Days Customer20
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateFITC
- Gene ID701
- Target nameBUB1B
- Target descriptionBUB1 mitotic checkpoint serine/threonine kinase B
- Target synonymsBub1A; BUB1B, mitotic checkpoint serine/threonine kinase; BUB1beta; BUBR1; budding uninhibited by benzimidazoles 1 homolog beta; hBUBR1; MAD3/BUB1-related protein kinase; MAD3L; mitotic checkpoint kinase MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MVA1; SSK1
- HostRabbit
- IsotypeIgG
- Protein IDO60566
- Protein NameMitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Scientific DescriptionEssential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203