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CHIR-99021 HCl [1797989-42-4]
T2310L
Overview
- SupplierTargetMol Chemicals
- Product NameCHIR-99021 HCl [1797989-42-4]
- Delivery Days Customer4
- CAS Number1797989-42-4
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameCHIR-99021 HCl
- Molecular FormulaC22H19Cl3N8
- Molecular Weight501.8
- Scientific DescriptionCHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3alpha/beta, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivity over CDC2, ERK2, and other protein kinases. Additionally, CHIR-99021 HCl serves as a robust activator of the Wnt/beta-catenin signaling pathway. Moreover, it exhibits the ability to enhance self-renewal in both mouse and human embryonic stem cells. Furthermore, CHIR-99021 HCl induces autophagy [1] [2] [3].
- Shelf life instruction3 years
- SMILESCl.N#CC1=CN=C(C=C1)NCCNC=2N=CC(C3=NC=C(N3)C)=C(N2)C=4C=CC(Cl)=CC4Cl
- Storage Instruction-20°C
- UNSPSC12352200
References
- Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.Read more