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CIQ

HY-18699
MedChem Express
CAS Number486427-17-2
DownloadMSDS
Product group Chemicals
Estimated Purity99.75
Molecular Weight467.94
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Overview

  • Supplier
    MedChem Express
  • Product Name
    CIQ [486427-17-2]
  • Delivery Days Customer
    10
  • CAS Number
    486427-17-2
  • Certification
    Research Use Only
  • Estimated Purity
    99.75
  • Molecular Formula
    C26H26ClNO5
  • Molecular Weight
    467.94
  • Scientific Description
    CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. IC50 value: 2.7 microM (EC50, for NR2C) and 2.8 microM (EC50, NR2D) Target: NMDA receptor CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 microM, respectively), with no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses. CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinsons disease models.
  • SMILES
    O=C(C1=CC=CC(Cl)=C1)N2C(COC3=CC=C(OC)C=C3)C4=C(C=C(OC)C(OC)=C4)CC2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200