H2AFX antibody
ORB106884
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
Overview
- SupplierBiorbyt
- Product NameH2AFX antibody
- Delivery Days Customer10
- ApplicationsWestern Blot
- Applications SupplierWB: 1:1000 WB
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID938CT5.1.1
- HostMouse
- IsotypeIgG1
- Scientific DescriptionMouse monoclonal to H2AFX. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
- ReactivityHuman
- UNSPSC12352203