Bio-Connect

Integrin alpha 4 antibody [HP2/1]

Research Use Only
GTX76407
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
Product group Antibodies
ReactivityBovine, Equine, Feline, Goat, Human, Mammals, Mink, Monkey, Mouse, Porcine, Primate, Rabbit, Rat
TargetITGA4
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    GeneTex
  • Product Name
    Integrin alpha 4 antibody [HP2/1]
  • Delivery Days Customer
    9
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    HP2/1
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3676
  • Target name
    ITGA4
  • Target description
    integrin subunit alpha 4
  • Target synonyms
    269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49D; IA4; integrin alpha-4; integrin alpha-IV; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohns disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
  • Reactivity
    Bovine, Equine, Feline, Goat, Human, Mammals, Mink, Monkey, Mouse, Porcine, Primate, Rabbit, Rat
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes. Hernandez AA et al., 2020 Nov 15, J Immunol
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  • Enhanced Integrin alpha4beta1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes. Abplanalp WT et al., 2016 Nov, Diabetes
    Read more