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Chemical Structure
Meleagrin [71751-77-4]
![Research Use Only](static/images/certificates/ruo.jpg)
AG-CN2-0451
Overview
- SupplierAdipoGen Life Sciences
- Product NameMeleagrin [71751-77-4]
- Delivery Days Customer10
- CAS Number71751-77-4
- CertificationResearch Use Only
- Estimated Purity>90%
- Molecular FormulaC23H23N5O4
- Molecular Weight433.5
- Scientific DescriptionChemical. CAS: 71751-77-4. Formula: C23H23N5O4. MW: 433.5. Isolated from Penicillium sp. Mycotoxin. Alkaloid antibiotic. Bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor. Antineoplastic activity. Moderate cytotoxicity against A-549 and HL-60 cell lines. Induces cell cycle arrest through G2/M phase, presumably by inhibiting tubulin polymerization. Antifouling agent against the barnacle Balanus amphitrite. - Mycotoxin. Alkaloid antibiotic. Bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor. Antineoplastic activity. Moderate cytotoxicity against A-549 and HL-60 cell lines. Induces cell cycle arrest through G2/M phase, presumably by inhibiting tubulin polymerization. Antifouling agent against the barnacle Balanus amphitrite.
- SMILESCON1C2=C(C=CC=C2)[C@@]2(C=C(O)C(=O)N3C(=CC4=CN=CN4)C(=O)N[C@@]123)C(C)(C)C=C
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200
References
- Studies on fungal products. VII. The structures of meleagrin and 9-O-p-bromobenzoylmeleagrin: K. Kawai, et al.; Chem. Pharm. Bull. 32, 94 (1984)
- Study of the alkaloid composition of the food-infecting penicilles: T.A. Reshetilova, et al.; Food Addit. Contam. 12, 461 (1995)
- Production of mycotoxins on artificially and naturally infested building materials: K.F. Nielsen, et al.; Mycopathologia 145, 43 (1999)
- Alkaloids from a deep ocean sediment-derived fungus Penicillium sp. and their antitumor activities: L. Du, et al.; J. Antibiot. 63, 165 (2010)
- iTRAQ-based proteomic profiling of the barnacle Balanus amphitrite in response to the antifouling compound meleagrin: Z. Han, et al.; J. Proteome Res. 12, 2090 (2013)
- Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action: C.J. Zheng, et al.; PLoS One 8, e78922 (2013)