Phospho-SMC1A (Ser957) Antibody
CSB-PA581416
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetSMC1A
Overview
- SupplierCusabio
- Product NamePhospho-SMC1A (Ser957) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID8243
- Target nameSMC1A
- Target descriptionstructural maintenance of chromosomes 1A
- Target synonymsCDLS2; DEE85; DXS423E; EIEE85; epididymis secretory sperm binding protein; SB1.8; segregation of mitotic chromosomes 1; SMC protein 1A; SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1alpha; SMC-1-alpha; SMC1L1; SMCB; structural maintenance of chromosomes protein 1A
- HostRabbit
- IsotypeIgG
- Protein IDQ14683
- Protein NameStructural maintenance of chromosomes protein 1A
- Scientific DescriptionInvolved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. Yang XM. et al. (2004) Mol Cell Biol. 24(12): 5290-5303. Kim ST. et al. (2002) Genes Dev. 16(5): 560-570. Revenkova E.et al. (2001) Mol Cell Biol. 21(20): 6984-6998
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C
- UNSPSC12352203