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ProTx III

Research Use Only
TP1969
TargetMol Chemicals
Molecular Weight3802.41
Product group Chemicals
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    ProTx III
  • Delivery Days Customer
    999
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    ProTx III
  • Molecular Formula
    C162H246N52O43S6
  • Molecular Weight
    3802.41
  • Scientific Description
    Potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 uM. Demonstrates analgesic activity in vivo; antagonizes effects of scorpion-venom toxin OD1 at Nav1.7.
  • Shelf life instruction
    3 years
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Cardoso et al (2015) Identification and characterization of ProTx-III [mu-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula thrixopelma pruriens. Mol.Pharmacol. 88 291 PMID:
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