SHMT2 antibody
GTX125939
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetSHMT2
Overview
- SupplierGeneTex
- Product NameSHMT2 antibody
- Delivery Days Customer9
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID6472
- Target nameSHMT2
- Target descriptionserine hydroxymethyltransferase 2
- Target synonymsepididymis secretory sperm binding protein Li 51e; GLY A+; GLYA; glycine auxotroph A, human complement for hamster; glycine hydroxymethyltransferase; HEL-S-51e; NEDCASB; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase, mitochondrial; serine methylase; SHMT; threonine aldolase
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes. Chu H et al., 2022 Jan 18, Anal ChemRead more
- Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation. Liao Y et al., 2021 Apr 16, Cancer Cell IntRead more
- Folate can promote the methionine-dependent reprogramming of glioblastoma cells towards pluripotency. Zgheib R et al., 2019 Aug 8, Cell Death DisRead more
- Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer. Lin C et al., 2019 Feb 12, Cell Death DisRead more
- Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer. Lo YW et al., 2015 Apr, J Cell Mol MedRead more