SYVN1 antibody, PAb
![Research Use Only](static/images/certificates/ruo.jpg)
ORB67250
Overview
- SupplierBiorbyt
- Product NameSYVN1 antibody, PAb
- Delivery Days Customer16
- ApplicationsWestern Blot
- Applications SupplierWB:1:500-1:2000 WB
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Scientific DescriptionRabbit polyclonal to SYVN1.E3 ubiquitin-protein ligase synoviolin (SYVN1) is a multi-pass membrane protein that belongs to theHRD1 family. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically fromendoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting theirdegradation. SYVN1 protects cells from ER stress-induced apoptosis and protects neurons fromapoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promotingtheir degradation. It sequesters p53/TP53 in the cytoplasm and promotes its degradation, therebynegatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203