Cyclin D1 antibody [DCS-6]

GeneTex

Cyclin D1 antibody [DCS-6]

9

Does not cross-react with other D-type cyclins.

WB: 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

DCS-6

Unconjugated

CCND1

cyclin D1

B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1 oncogene; D11S287E; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31

Mouse

IgG2a

G1/S-specific cyclin-D1

During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by activating Cdks. Early in the G1 phase of the cell cycle cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2.

Human, Monkey, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203