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Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)(CCND1/2593), CF405S conjugate, 0.1mg/mL [26628-22-8]

Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)(CCND1/2593), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC042593
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetCCND1
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Overview

  • Supplier
    Biotium
  • Product Name
    Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)(CCND1/2593), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    CCND1/2593
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID595
  • Target name
    CCND1
  • Target description
    cyclin D1
  • Target synonyms
    B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1 oncogene; D11S287E; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP24385
  • Protein Name
    G1/S-specific cyclin-D1
  • Scientific Description
    Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203