![Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)(CCND1/2593), CF405S conjugate, 0.1mg/mL [26628-22-8] Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)(CCND1/2593), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2021/02/view_image-311.jpeg)
Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)(CCND1/2593), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC042593
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetCCND1
Overview
- SupplierBiotium
- Product NameCyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)(CCND1/2593), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDCCND1/2593
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID595
- Target nameCCND1
- Target descriptioncyclin D1
- Target synonymsB-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1 oncogene; D11S287E; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
- HostMouse
- IsotypeIgG1
- Protein IDP24385
- Protein NameG1/S-specific cyclin-D1
- Scientific DescriptionRecognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203