Cyclo(L-Leu-L-Trp) [15136-34-2]

TargetMol Chemicals

Cyclo(L-Leu-L-Trp) [15136-34-2]

16

15136-34-2

Chemical

Research Use Only

Cyclo(L-Leu-L-Trp)

C17H21N3O2

299.374

Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite initially derived from Penicillium, exhibiting antibacterial (MICs = 125-1000 microg/ml) and antifungal activities (MICs = 8-64 microg/ml). It also demonstrates antioxidant properties by reducing the production of hydroxy radicals, as evidenced in an electron spin resonance (ESR) spectroscopy assay (IC50 = 1.8 microM). Additionally, Cyclo(L-Leu-L-Trp) has been identified as a bitter compound capable of quickly crossing rat taste cell membranes ex vivo at a 1 mM concentration. Furthermore, it acts as a melatonin receptor agonist in X. laevis melanophores, suppressing cAMP accumulation at a 20 microM concentration, with this effect being negated by the melatonin receptor antagonist luzindole.

3 years

CC(C)C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O

-20°C

12352200