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ProductsBack/Cyclosporin D [63775-96-2]
Chemical Structure
Chemical Structure
Chemical Structure

Cyclosporin D [63775-96-2]

Research Use Only
AG-CN2-0445
AdipoGen Life Sciences
CAS Number63775-96-2
DownloadDatasheet
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Product group Chemicals
Estimated Purity>97% (HPLC)
Molecular Weight1216.7
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Cyclosporin D [63775-96-2]
  • Delivery Days Customer
    10
  • CAS Number
    63775-96-2
  • Certification
    Research Use Only
  • Estimated Purity
    >97% (HPLC)
  • Hazard Information
    Danger,Non-hazardous
  • Molecular Formula
    C63H113N11O12
  • Molecular Weight
    1216.7
  • Scientific Description
    Chemical. CAS: 63775-96-2. Formula: C63H113N11O12. MW: 1216.7. Isolated from Fusarium solani. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo. Antifungal. Moderate immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079). Moderate inhibitor of formyl peptide-induced superoxide formation. - Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo. Antifungal. Moderate immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079). Moderate inhibitor of formyl peptide-induced superoxide formation.
  • SMILES
    [H][C@@]1([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)C(NC1=O)C(C)C)C(C)C
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Effect of column temperature and eluent flow rate on the high performance liquid chromatographic analysis of cyclosporin a and d: K.A. Mereish & C.T. Ueda; Pharm. Res. 1, 245 (1984)
  • The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988)
  • Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation: K. Wentzel-Seifert, et al.; J. Immunol. 147, 1940 (1991)