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ProductsBack/Cyclosporin H [83602-39-5]
Chemical Structure
Chemical Structure
Chemical Structure

Cyclosporin H [83602-39-5]

Research Use Only
AG-CN2-0447
AdipoGen Life Sciences
CAS Number83602-39-5
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Product group Chemicals
Estimated Purity>97% (HPLC)
Molecular Weight1202.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Cyclosporin H [83602-39-5]
  • Delivery Days Customer
    10
  • CAS Number
    83602-39-5
  • Certification
    Research Use Only
  • Estimated Purity
    >97% (HPLC)
  • Hazard Information
    Danger,Non-hazardous
  • Molecular Formula
    C62H111N11O12
  • Molecular Weight
    1202.6
  • Scientific Description
    Chemical. CAS: 83602-39-5. Formula: C62H111N11O12. MW: 1202.6. Isolated from Tolypocladium inflatum. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo. Antifungal. Potent and effective inhibitor of formyl peptide receptor (FPR) and formyl peptide-induced superoxide formation. Shows no immunosuppresive activity like other cyclosporins. - Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo. Antifungal. Potent and effective inhibitor of formyl peptide receptor (FPR) and formyl peptide-induced superoxide formation. Shows no immunosuppresive activity like other cyclosporins.
  • SMILES
    [H][C@@]1([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)C(CC)NC1=O)C(C)C
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988)
  • Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation: K. Wenzel-Seifert, et al.; J. Immunol. 147, 1940 (1991)
  • Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor: A.L. Stenfeldt, et al.; Inflammation 30, 224 (2007)