The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA122670(CYFIP2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA122670(CYFIP2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200)
CYFIP2 Antibody
CSB-PA122670
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCYFIP2
Overview
- SupplierCusabio
- Product NameCYFIP2 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID26999
- Target nameCYFIP2
- Target descriptioncytoplasmic FMR1 interacting protein 2
- Target synonymscytoplasmic FMR1-interacting protein 2; DEE65; EIEE65; p53-inducible protein 121; PIR121
- HostRabbit
- IsotypeIgG
- Protein IDQ96F07
- Protein NameCytoplasmic FMR1-interacting protein 2
- Scientific DescriptionCYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203