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ProductsBack/Cytisine [485-35-8]
Chemical Structure
Chemical Structure
Chemical Structure

Cytisine [485-35-8]

Research Use Only
AG-CN2-0075
AdipoGen Life Sciences
CAS Number485-35-8
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Product group Chemicals
Estimated Purity>99%
Molecular Weight190.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Cytisine [485-35-8]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    485-35-8
  • Certification
    Research Use Only
  • Estimated Purity
    >99%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C11H14N2O
  • Molecular Weight
    190.2
  • Scientific Description
    Chemical. CAS: 485-35-8. Formula: C11H14N2O. MW: 190.2. Isolated from Laburnum anagyroides seeds. Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities. Used for smoking cessation. Might be used for binge-like ethanol drinking cessation. Iron-chelator and hydroxyl radical scavanger. Has antidepressant properties. Used in forensics in novel surface molecular imprinting techniques. - Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities. Used for smoking cessation. Might be used for binge-like ethanol drinking cessation. Iron-chelator and hydroxyl radical scavanger. Has antidepressant properties. Used in forensics in novel surface molecular imprinting techniques.
  • SMILES
    O=C1C=CC=C2C3CNCC(C3)CN12
  • Storage Instruction
    2°C to 8°C,-20°C
  • UN Number
    UN 2811
  • UNSPSC
    12352200

References

  • Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit: R.L. Papke & S.F. Heinemann; Mol. Pharmacol. 45, 142 (1994)
  • Evidence for spare nicotinic acetylcholine receptors and a beta 4 subunit in bovine adrenal chromaffin cells: studies using bromoacetylcholine, epibatidine, cytisine and mAb35: B.W. Wenger, et al.; J. Pharmacol. Exp. Ther. 281, 905 (1997)
  • Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo: B. Ferger, et al.; Eur. J. Pharmacol. 360, 155 (1998)
  • Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors: L.M. Houlihan, et al.; J. Neurochem. 78, 1029 (2001)
  • Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates: J. Zhang & J.H. Steinbach; Brain Res. 959, 98 (2003)
  • Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes: Y.E. Slater, et al.; Neuropharmacology 44, 503 (2003)
  • Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy: P. Tutka & W. Zatonski; Pharmacol. Rep. 58, 777 (2006) (Review)
  • Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice: Y.S. Mineur, et al.; Neuropharmacology 52, 1256 (2007)
  • Cytisine for smoking cessation: a research agenda: J.F. Etter, et al.; Drug Alcohol Depend. 92, 3 (2008) (Review)
  • Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors: Y.F. Li, et al.; Auton. Neurosci. 154, 14 (2010)