![Cytochrome C(CTC05), CF405S conjugate, 0.1mg/mL [26628-22-8] Cytochrome C(CTC05), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2016/12/BNUB0887-0-1.jpg)
Cytochrome C(CTC05), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC040887
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityAmphibian, Avian, Bovine, Canine, Drosophila, Equine, Human, Mouse, Rat
TargetCYCS
Overview
- SupplierBiotium
- Product NameCytochrome C(CTC05), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDCTC05
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID54205
- Target nameCYCS
- Target descriptioncytochrome c, somatic
- Target synonymsCYC; cytochrome c; HCS; THC4
- HostMouse
- IsotypeIgG2b
- Protein IDP99999
- Protein NameCytochrome c
- Scientific DescriptionCytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityAmphibian, Avian, Bovine, Canine, Drosophila, Equine, Human, Mouse, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203