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Cytokeratin 6(LHK6), CF640R conjugate, 0.1mg/mL [26628-22-8]

Cytokeratin 6(LHK6), CF640R conjugate, 0.1mg/mL [26628-22-8]

BNC400675
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetKRT6A
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Overview

  • Supplier
    Biotium
  • Product Name
    Cytokeratin 6(LHK6), CF640R conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    LHK6
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID3853
  • Target name
    KRT6A
  • Target description
    keratin 6A
  • Target synonyms
    CK6A; CK6C; CK-6C; CK6D; CK-6E; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; K6A; K6C; K6D; keratin 6A, , type II; keratin 6A, type II; keratin, epidermal type II, K6A; keratin, type II cytoskeletal 6A; KRT6C; KRT6D; PC3; type-II keratin Kb6
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    This MAb recognizes a protein of 56 kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203