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Cyy-272

Research Use Only
HY-169052
MedChem Express
Molecular Weight435.47
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Cyy-272
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C23H23F2N7
  • Molecular Weight
    435.47
  • Scientific Description
    Cyy-272 is an orally active JNK inhibitor with IC50 values of 1.25 microM for JNK1, 1.07 microM for JNK2, and 1.24 microM for JNK3. Cyy-272 exerts anti-inflammatory effects by inhibiting JNK phosphorylation, thereby alleviating acute lung injury (ALI) induced by lipopolysaccharide (LPS, HY-D1056). Additionally, Cyy-272 significantly reduces inflammation in cardiomyocytes and cardiac tissue induced by high lipid concentrations, further mitigating cardiac hypertrophy, fibrosis, and apoptosis. Cyy-272 can be used in the study of obese cardiomyopathy[1].
  • SMILES
    CC1=C(N=C(N=C1)NC2=CC=C(C=C2)N3CCC(F)(CC3)F)NC4=CC=C5C=NNC5=C4
  • UNSPSC
    12352200