CZC-25146 (hydrochloride)
HY-15800
Overview
- SupplierMedChem Express
- Product NameCZC-25146 (hydrochloride) [1330003-04-7]
- Delivery Days Customer10
- CAS Number1330003-04-7
- CertificationResearch Use Only
- Molecular FormulaC22H26ClFN6O4S
- Molecular Weight525.00
- Scientific DescriptionCZC-25146 hydrochloride is a potent LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 hydrochloride inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 hydrochloride prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 hydrochloride exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 hydrochloride can increase normal alpha-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 hydrochloride can be used to research Parkinsons disease and liver diseases[1][2][3].
- SMILESCS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2F)=O.Cl
- UNSPSC12352200