D-erythro-Dihydrosphingosine 1-phosphate [19794-97-9]

Name: D-erythro-Dihydrosphingosine 1-phosphate [19794-97-9]
SKU: AG-CR1-0005_A27
Price: 104 EUR
Availability: BackOrder

AG-CR1-0005

Estimated Purity>98% (NMR)

Product group Chemicals

Molecular Weight381.5

Overview

Supplier
AdipoGen Life Sciences
Product Name
D-erythro-Dihydrosphingosine 1-phosphate [19794-97-9]
Delivery Days Customer
10
Certification
Research Use Only
Estimated Purity
>98% (NMR)
Hazard Information
Non-hazardous
Molecular Formula
C18H40NO5P
Molecular Weight
381.5
Scientific Description
Chemical. CAS: 19794-97-9. Formula: C18H40NO5P. MW: 381.5. Saturated analog of sphingosine 1-phosphate (1-SP1). Ligand for sphingosine 1-phosphate (S1P/EDG) receptors. Negative control for intracellular effects of sphingosine 1-phosphate. Induces chemotaxis. Antifibrotic. - Saturated analog of sphingosine 1-phosphate (1-SP1). Ligand for sphingosine 1-phosphate (S1P/EDG) receptors [1,3]. Negative control for intracellular effects of sphingosine 1-phosphate [1]. Induces chemotaxis [2]. Antifibrotic [4].
SMILES
CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)COP(O)(O)=O
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival: J.R. van Brocklyn, et al.; J. Cell Biol. 142, 229 (1998)
Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis: F. Wang, et al.; JBC 274, 35343 (1999)
Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218: J.R. van Brocklyn, et al. JBC 274, 4626 (1999)
Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels: Arthritis Rheum. 62, 2117 (2010)