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ProductsBack/D-Mannoheptulose [3615-44-9]
Chemical Structure
Chemical Structure
Chemical Structure

D-Mannoheptulose [3615-44-9]

Research Use Only
AG-CR1-3695
AdipoGen Life Sciences
CAS Number3615-44-9
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight210.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    D-Mannoheptulose [3615-44-9]
  • Delivery Days Customer
    10
  • CAS Number
    3615-44-9
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C7H14O7
  • Molecular Weight
    210.2
  • Scientific Description
    Chemical. CAS: 3615-44-9. Formula: C7H14O7. MW: 210.2. . Naturally occurring heptose in avocado fruit. Hexokinase (HK) and glucokinase inhibitor in diverse organisms by competing with D-glucose. Useful agent for immunometabolism research. Blocks glucose phosphorylation by blocking hexokinase. Prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein and consequently inhibiting the rate limiting step of glycolysis. Blocks glucose oxidation and glucose-mediated insulin release in pancreatic islet cells. - Naturally occurring heptose in avocado fruit. Hexokinase (HK) and glucokinase inhibitor in diverse organisms by competing with D-glucose. Useful agent for immunometabolism research. Blocks glucose phosphorylation by blocking hexokinase. Prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein and consequently inhibiting the rate limiting step of glycolysis. Blocks glucose oxidation and glucose-mediated insulin release in pancreatic islet cells.
  • SMILES
    OC[C@@H]1[C@@H](O)[C@H](O)[C@H](O)C(O)(CO)O1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Inhibition of glucose phosphorylation by mannoheptulose: H.G. Coore & P.J. Randle; Biochem. J. 91, 56 (1964)
  • Enzymes of glucose metabolism in normal mouse pancreatic islets: S.J.H. Ashcroft & P.J. Randle; Biochem. J. 119, 5 (1970)
  • Interrelationship of islet metabolism, adenosine triphosphate content and insulin release: S.J.H. Ashcroft, et al.; Biochem. J. 132, 223 (1973)
  • High Km glucose-phosphorylating (glucokinase) activities in a range of tumor cell lines and inhibition of rates of tumor growth by the specific enzyme inhibitor mannoheptulose: M. Board, et al.; Cancer Res. 55, 3278 (1995)
  • Effect of a glucokinase inhibitor on energy production and insulin release in pancreatic islets: I.R. Sweet, et al.; Am. J. Physiol. 271, E606 (1996)
  • Interference of D-mannoheptulose with D-glucose phosphorylation, metabolism and functional effects: comparison between liver, parotid cells and pancreatic islets: O. Scruel, et al.; Mol. Cell Biochem. 187, 113 (1998)
  • Overexpression of Arabidopsis hexokinase in tomato plants inhibits growth, reduces photosynthesis, and induces rapid senescence: N. Dai, et al.; Plant Cell 11, 1253 (1999)
  • D-mannoheptulose phosphorylation by hexokinase isoenzymes: P. Courtois, et al.; Int. J. Mol. Med. 7, 359 (2001)
  • Dissimilar effects of D-mannoheptulose on the phosphorylation of alpha- versus beta-D-glucose by either hexokinase or glucokinase: Y. Zhang, et al.; Int. J. Mol. Med. 14, 107 (2004)
  • Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator: D. Johnson, et al.; Diabetes 56, 1694 (2007)