(D)-PPA 1 [1620813-53-7]

TargetMol Chemicals

(D)-PPA 1 [1620813-53-7]

9

Research Use Only

C70H98N20O21

1555.67

PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 microM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.

C([C@H](NC([C@H](NC([C@@H](CC1=CC=C(O)C=C1)NC([C@@H](CC(N)=O)N)=O)=O)CO)=O)CCCCN)(=O)N2[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC3=CC=C(O)C=C3)C(N[C@H](CC4=CN=CN4)C(N[C@H](CC5=CC=CC=C5)C(O)=O)=O)=O)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CC(O)=O)=O)[C@H](C)O)=O)CCC2

-20°C

12352200