Bio-Connect

DA-143

Research Use Only
HY-169121
MedChem Express
Molecular Weight576.71
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    DA-143
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C34H32N4O3S
  • Molecular Weight
    576.71
  • Scientific Description
    DA-143 is a selective DNA-PKcs inhibitor (IC50: 2.5 nM), and the IC50s for mTOR, PI3Kdelta, and ATM are 280 nM, 106 nM and 6,594 nM respectively. DA-143 blocks phosphorylation of DNA-PKcs substrates. DA-143 sensitizes cancer cells to Doxorubicin (HY-15142)[1].
  • SMILES
    O=C1C=C(OC2=C1C=CC=C2C3=C4SC5=CC=C(C=C5C4=CC=C3)C6=CN(N=C6)CCN7CCCC7)N8CCOCC8
  • UNSPSC
    12352200