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ProductsBack/DA-6886 [1645260-76-9]
CgoaEWY7T_KEMbzkAAAAACR-l2E232.png
CgoaEWY7T_KEMbzkAAAAACR-l2E232.png
CgoaEWY7T_KEMbzkAAAAACR-l2E232.png

DA-6886 [1645260-76-9]

Research Use Only
T27117
TargetMol Chemicals
Molecular Weight443.37
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Product group Chemicals
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    DA-6886 [1645260-76-9]
  • Delivery Days Customer
    4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    DA-6886
  • Molecular Formula
    C19H28Cl2N6O2
  • Molecular Weight
    443.37
  • Scientific Description
    DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 value of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels.
  • Shelf life instruction
    3 years
  • SMILES
    Cl.O=C(NCC1CCN(CCCN2N=NC=C2)CC1)C3=CC(Cl)=C(N)C=C3OC
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Lee MJ, et al. Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice. Eur J Pharmacol. 2014;735:115-122.
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