DA-E 5090

MedChem Express

DA-E 5090

5

Research Use Only

C17H18O4

286.32

DA-E 5090 is an orally effective inhibitor of IL-1 production that can be converted into a pharmacologically active deacetylated form (DA-E5090) in vivo. In this study, the effects of DA-E5090 on IL-1 production in vitro were examined by LPS-stimulated human monocytes. The results showed that DA-E5090 could dose-dependently inhibit the production of IL-1alpha and IL-1beta (1-10 microM) by LPS-stimulated human monocytes, as determined by LAF assay and ELISA. Northern blotting analysis showed that DA-E5090 inhibited the transcription of IL-1alpha and IL-1beta mRNA.

O=C(/C(C)=C\C1=C2C=CC=C(C2=C(C(OC)=C1)O)CC)O

12352200