Dacomitinib metabolite M1/2

MedChem Express

Dacomitinib metabolite M1/2

9

Research Use Only

C27H32ClFN6O4S

591.10

Dacomitinib metabolite M1/2 is a potent inhibitor of both wild-type (WT) EGFR and the T790M mutation, demonstrating significant activity against acquired resistance mechanisms in EGFR-mutant non-small-cell lung cancer (NSCLC).

COC(C(NC(CC(SC[C@H](N)C(O)=O)CN1CCCCC1)=O)=C2)=CC3=C2C(NC4=CC(Cl)=C(C=C4)F)=NC=N3

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