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ProductsBack/Dacomitinib Monohydrate [1042385-75-0]

Dacomitinib Monohydrate [1042385-75-0]

Research Use Only
D0006
LKT Laboratories
Estimated Purity≥99%
Product group Chemicals
€ 156,00
1 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Dacomitinib Monohydrate [1042385-75-0]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥99%
  • Format
    Soluble in water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMSO (19 mg/ml at 25 °C), and 1% DMSO/30% polyethylene glycol/1% Tween 80, pH 9 (10 mg/ml at 25 °C).
  • Scientific Description
    EGFR inhibitor.; PF-00299804
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Kalous O, Conklin D, Desai AJ, et al. Dacomitinib (PF-00299804), an irreversible Pan-HER inhibitor, inhibits proliferation of HER2-amplified breast cancer cell lines resistant to trastuzumab and lapatinib. Mol Cancer Ther. 2012 Sep;11(9):1978-87. PMID: 22761403. Gonzales AJ, Hook KE, Althaus IW, et al. Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor. Mol Cancer Ther. 2008 Jul;7(7):1880-9. PMID: 18606718.